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Articles (33)
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Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease

Christopher J. Helal, Zhijun Kang, John C. Lucas, Thomas Gant, Michael K. Ahlijanian, Joel B. Schachter, Karl E.G. Richter, James M. Cook, Frank S. Menniti, Kristin Kelly, Scot Mente, Jay Pandit, Nata

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2009

Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer’s disease

Easton, Amy, Sankaranarayanan, Sethu, Tanghe, An, Terwel, Dick, Lin, Alan X., Hoque, Nina, Bourin, Clotilde, Gu, Huidong, Ahlijanian, Michael, Bristow, Linda

Journal:

Psychopharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 386 KB

english, 2013

On-Line Monitoring of Vacuum Dryers Using Mass Spectrometry

am Ende, David J., Preigh, Michael J., Hettenbach, Kevin, Ahlijanian, Paul, Ward, Howard W.

Journal:

Organic Process Research & Development

Année:

2000

Langue:

english

Fichier:

PDF, 88 KB

english, 2000

40 Hz Auditory Steady State Response is a Pharmacodynamic Biomarker for Cortical NMDA Receptors

Sivarao, Digavalli V, Chen, Ping, Senapati, Arun, Yang, Yili, Fernandes, Alda, Benitex, Yulia, Whiterock, Valerie, Li, Yu-Wen, Ahlijanian, Michael K

Journal:

Neuropsychopharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2016

Ca2+ channel toxins: Tools to study channel structure and function

Nicholas A. Saccomano, Michael K. Ahlijanian

Journal:

Drug Development Research

Année:

1994

Langue:

english

Fichier:

PDF, 2.72 MB

english, 1994

Calmodulin plays a dominant role in determining neurotransmitter regulation of neuronal adenylate cyclase

Dermot M. F. Cooper, Michael K. Ahlijanian, Edward Perez-Reyes

Journal:

Journal of Cellular Biochemistry

Année:

1988

Langue:

english

Fichier:

PDF, 669 KB

english, 1988

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

Christopher J. Helal, Mark A. Sanner, Christopher B. Cooper, Thomas Gant, Mavis Adam, John C. Lucas, Zhijun Kang, Stanley Kupchinsky, Michael K. Ahlijanian, Bonnie Tate, Frank S. Menniti, Kristin Kell

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 289 KB

english, 2004

Distinct interactions between Ca2+/calmodulin and neurotransmitter stimulation of adenylate cyclase in striatum and hippocampus

Michael K. Ahlijanian, Dermot M. F. Cooper

Journal:

Cellular and Molecular Neurobiology

Année:

1988

Langue:

english

Fichier:

PDF, 551 KB

english, 1988

Ca2+/Calmodulin Distinguishes Between Guanyl-5′-yl-Imidodiphosphate-and Opiate-Mediated Inhibition of Rat Striatal Adenylate Cyclase

Michael K. Ahlijanian, Marianne K. Halford, Dermot M. F. Cooper

Journal:

Journal of Neurochemistry

Année:

1987

Langue:

english

Fichier:

PDF, 783 KB

english, 1987

Evidence for Neuropathology in Transgenic Mice Overexpressing p25, an Activator of cdk5

Michael K. Ahlijanian

Journal:

CNS Drug Reviews

Année:

2000

Langue:

english

Fichier:

PDF, 11 KB

english, 2000

Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons

Westenbroek, Ruth E., Ahlijanian, Michael K., Catterall, William A.

Journal:

Nature

Année:

1990

Fichier:

PDF, 597 KB

1990

Effects of (−)-N6-(R-phenylisopropyl)-adenosine (PIA) and caffeine on nociception and morphine-induced analgesia, tolerance and dependence in mice

Michael K. Ahlijanian, A.E. Takemori

Journal:

European Journal of Pharmacology

Année:

1985

Langue:

english

Fichier:

PDF, 692 KB

english, 1985

The effect of chronic administration of caffeine on morphine-induced analgesia, tolerance and dependence in mice

Michael K. Ahlijanian, A.E. Takemori

Journal:

European Journal of Pharmacology

Année:

1986

Langue:

english

Fichier:

PDF, 605 KB

english, 1986

Cross-tolerance studies between caffeine and (−)-N6-(phenylisopropyl)-adenosine (PIA) in mice

Michael K. Ahlijanian, A.E. Takemori

Journal:

Life Sciences

Année:

1986

Langue:

english

Fichier:

PDF, 562 KB

english, 1986

Novel human CSF tau-fragment and pTau assays for distinguishing Alzheimer's from control subjects

Sethu Sankaranarayanan, Jere Meredith, Valerie Guss, Alan Xu-Lin, Holly Soares, Kaj Blennow, Charles Albright, Michael Ahlijanian

Journal:

Alzheimer's & Dementia

Année:

2012

Langue:

english

Fichier:

PDF, 59 KB

english, 2012

Novel tau fragments are present in human CSF

Jere Meredith, Randall Slemmon, Valerie Guss, Anthony Lanzetti, Sethu Sankaranarayanan, Holly Soares, Kaj Blennow, Charlie Albright, Michael Ahlijanian

Journal:

Alzheimer's & Dementia

Année:

2012

Langue:

english

Fichier:

PDF, 435 KB

english, 2012

Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina

Ahlijanian, Michael K., Westenbroek, Ruth E., Catterall, William A.

Journal:

Neuron

Année:

1990

Langue:

english

Fichier:

PDF, 8.08 MB

english, 1990

Compound Screening In A Drosophila melanogaster Alzheimer's Disease Model Using A Behavioral Readout

Mahoney, Matt B., Singh, Carol M., Diggins, Lenard T., Keefe, Devin, Lund, Emily, O'Neil, Phil, Sigel, Eric, Symonds, Jim, Villaluz, Alfred, Ahlijanian, Michael K., Palfreyman, Michael G.

Journal:

Alzheimer's & Dementia

Année:

2009

Langue:

english

Fichier:

PDF, 96 KB

english, 2009

Identification and Differential Subcellular Localization of the Neuronal Class C and Class D L-Type Calcium Channel α1 Subunits

Johannes W. Hell, Ruth E. Westenbroek, Concepcion Warner, Michael K. Ahlijanian, Ward Prystay, Mary M. Gilbert, Terry P. Snutch and William A. Catterall

Journal:

The Journal of Cell Biology

Année:

1993

Langue:

english

Fichier:

PDF, 4.76 MB

english, 1993

Interpreting Alzheimer’s disease clinical trials in light of the effects on amyloid-β

Jeremy H Toyn,Michael K Ahlijanian

Journal:

Alzheimer's Research & Therapy

Année:

2014

Langue:

english

Fichier:

PDF, 277 KB

english, 2014

Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration

Scherling, Carole S., Hall, Tracey, Berisha, Flora, Klepac, Kristen, Karydas, Anna, Coppola, Giovanni, Kramer, Joel H., Rabinovici, Gil, Ahlijanian, Michael, Miller, Bruce L., Seeley, William, Grinber

Journal:

Annals of Neurology

Année:

2014

Langue:

english

Fichier:

PDF, 562 KB

english, 2014

NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats

Sivarao, Digavalli V., Chen, Ping, Yang, Yili, Li, Yu-Wen, Pieschl, Rick, Ahlijanian, Michael K.

Journal:

Frontiers in Psychiatry

Année:

2014

Langue:

english

Fichier:

PDF, 733 KB

english, 2014

L-Type Calcium Channels in Insulin-Secreting Cells: Biochemical Characterization and Phosphorylation in RINm5F Cells

Safayhi, Hasan, Haase, Hannelore, Kramer, Ursel, Bihlmayer, Andrea, Roenfeldt, Monika, Ammon, Hermann P.T., Froschmayr, Monika, Cassidy, Tara N., Morano, Ingo, Ahlijanian, Michael K., Striessnig, Jörg

Journal:

Molecular Endocrinology

Année:

1997

Langue:

english

Fichier:

PDF, 773 KB

english, 1997

Molecular Cloning of the α-1 Subunit of an ω-Conotoxin-Sensitive Calcium Channel

Stefan J. Dubel, Terry V. B. Starr, Johannes Hell, Michael K. Ahlijanian, John J. Enyeart, William A. Catterall and Terry P. Snutch

Journal:

Proceedings of the National Academy of Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 1019 KB

english, 1992

APP Processing Is Regulated by Cytoplasmic Phosphorylation

Ming-Sum Lee, Shih-Chu Kao, Cynthia A. Lemere, Weiming Xia, Huang-Chun Tseng, Ying Zhou, Rachael Neve, Michael K. Ahlijanian and Li-Huei Tsai

Journal:

The Journal of Cell Biology

Année:

2003

Langue:

english

Fichier:

PDF, 2.38 MB

english, 2003

Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays

Newberry, Kim, Wang, Shuya, Hoque, Nina, Kiss, Laszlo, Ahlijanian, Michael K., Herrington, James, Graef, John D.

Journal:

Journal of Neurophysiology

Année:

2016

Langue:

english

Fichier:

PDF, 2.06 MB

english, 2016

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors

Wu, Yong-Jin, Guernon, Jason, Rajamani, Ramkumar, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Muckelbauer, Jodi, Chang, ChiehYing, Camac, Dan, Macor, John E., Thompson, Lorin A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 725 KB

english, 2016

Utility of high resolution accurate mass spectrometry (HRMS) in the mass isotopomer distribution analysis (MIDA) of CSF proteins modified by stable isotope labeling in mammals (SILAM) methodology applied to neurodegenerative diseases

Cantone, Joseph L., Polson, Craig, Wei, Cong, Guss, Valerie, Ahlijanian, Michael K., Meredith, Jere E., Drexler, Dieter M.

Journal:

Analytical Methods

Année:

2017

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2017

A functional NaV1.7-NavAb chimera with a reconstituted high affinity ProTx-II binding site

Rajamani, Ramkumar, Wu, Sophie, Rodrigo, Iyoncy, Gao, Mian, Low, Simon, Megson, Lisa, Wensel, David, Pieschl, Rick, Post-Munson, Debra, Watson, John, Langley, David R, Ahlijanian, Michael, Bristow, Li

Journal:

Molecular Pharmacology

Année:

2017

Langue:

english

Fichier:

PDF, 554 KB

english, 2017

Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry

Huang, Richard Y.-C., Iacob, Roxana E., Sankaranarayanan, Sethu, Yang, Ling, Ahlijanian, Michael, Tao, Li, Tymiak, Adrienne A., Chen, Guodong

Journal:

Journal of the American Society for Mass Spectrometry

Année:

2017

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2017

A randomized, single ascending dose study of intravenous BIIB092 in healthy participants

Qureshi, Irfan A., Tirucherai, Giridhar, Ahlijanian, Michael K., Kolaitis, Gerry, Bechtold, Clifford, Grundman, Michael

Journal:

Alzheimer s & Dementia Translational Research & Clinical Interventions

Année:

2018

Langue:

english

Fichier:

PDF, 386 KB

english, 2018

Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite

Zhang, Yunhui, Boy, Kenneth M., Wu, Yong-Jin, Ramirez, Antonio, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Zhuo, Xiaoliang, Johnson, Benjamin M., Denton, R. Rex, Olson, Richard E.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 527 KB

2020

Partial Rescue of the p35â/â Brain Phenotype by Low Expression of a Neuronal-Specific Enolase p25 Transgene

Patzke, Holger, Maddineni, Upendra, Ayala, Ramses, Morabito, Maria, Volker, Janet, Dikkes, Pieter, Ahlijanian, Michael K., Tsai, Li-Huei

Journal:

Journal of Neuroscience

Année:

2003

Fichier:

PDF, 576 KB

2003